Now showing items 15-17 of 17

    • A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B 

      Miranda-Miranda, Estefan; Scarcella, Silvana; Reynaud, Enrique; Narváez-Padilla, Verónica; Neira, Gisela; Mera y Sierra, Roberto; Aguilar-Díaz, Hugo; Cossio-Bayugar, Raquel (Comite editorial GENES, 2022-10-19)
      Fasciola hepatica anthelmintic resistance may be associated with the catalytic activity of xenobiotic metabolizing enzymes. The gene expression of one of these enzymes, identified as car boxylesterase B (CestB), was previously described as inducible in adult parasites under anthelmintic treatment and exhibited a single nucleotide polymorphism at position 643 that translates into a radical amino acid substitution at position 215 from Glutamic acid to Lysine. Alphafold 3D models of both allelic sequences exhibited a significant affinity pocket rearrangement and different ligand-docking modeling ...
    • Situación de la fasciolasis en Mendoza: nuevos desafíos de una enfermedad desatendida 

      Mera y Sierra, Roberto; Cuervo, Pablo; Sidoti, Laura; Deis, Erika; Fantozzi, Cecilia; Sohaefer, Noelia; Neira, Gisela; Di Cataldo, Sophía; Spongia, Silvina; Gerbeno, Leticia (Dirección de Investigación, Ciencia y Técnica. Ministerio de Salud. Mendoza, 2013-03)
      La fascioliasis es una enfermedad producida por los trematodos Fasciola hepatica y Fasciola gigantica, transmitida por caracoles acuáticos de la familia Lymnaeidae. Tradicionalmente era considerada una enfermedad de importancia veterinaria por el impacto que produce sobre el ganado, únicamente afectando a humanos en forma esporádica. Sin embargo, en años recientes, esta situación ha cambiado en forma drástica: de 2000 casos humanos reportados a nivel mundial entre 1970-1990, actualmente se ven afectados 17 millones de personas y otros 91 millones se encuentran en riesgo. La fascioliasis se ha ...
    • Vector Borne Diseases in Mid Western Argentina, First Report of Setaria Equina [Nematoda: Onchocercidae] in A Horse [Equus caballus] 

      Mera y Sierra, Roberto; Iranzo, José; Neira, Gisela (Comité editorial Austin Journal of Vector Borne Diseases, 2017-12-05)
      Vector borne diseases are spreading worldwide. Companion animals can be useful as sentinels for disease surveillance. Setaria spp. are filarial nematodes transmitted by Aedes spp. and Culex spp. Setaria equina has been reported in Asia, Africa and North America. This zoonotic nematode is frequently asymptomatic in horses, except during its erratic migrations. Filarial worms have a tropism for ocular and nervous tissues, having important implications in veterinary and public health. In mid west Argentina, Dirofilaria immitis has already been described affecting a woman and dogs. There are no ...