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dc.contributor.authorSolana, María Victoria
dc.contributor.authorMera y Sierra, Roberto
dc.contributor.authorScarcella, Silvana
dc.contributor.authorNeira, Gisela
dc.contributor.authorSolana, Hugo Daniel
dc.date.accessioned2020-10-07T13:24:55Z
dc.date.available2020-10-07T13:24:55Z
dc.date.issued2016
dc.identifier.citationSolana, M. V., Mera y Sierra R., Scarcella, S., Neira, G., Y Solana, H. D. (2016) In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs. Experimental Parasitology, 160, 49-53. https://doi.org/10.1016/j.exppara.2015.10.010en_US
dc.identifier.issn0014-4894
dc.identifier.urihttp://repositorio.umaza.edu.ar//handle/00261/1750
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0014489415300576?via%3Dihub#!
dc.description.abstractARTÍCULO PUBLICADO EN REVISTA EXTERNA.Anthelmintic resistance in livestock parasites is currently a worldwide problem. Fasciola hepatica is a cosmopolitan parasite which causes considerable loss in sheep and cattle production systems all over the world. Chemotherapy is currently the main tool available for its control. The intensive use of triclabendazole, the drug of choice for more than 20 years, has resulted in the development of resistant strains. The therapeutic options are adulticides such as closantel (salicylanilide anthelmintic that binds extensively to plasma albumin) to treat chronic fascioliasis in sheep, and cattle. In the present work, an Egg Hatch Assay (EHA) and morphometric studies were used to evaluate in vivo the ovicidal activity and morphology F. hepatica eggs, recovered from closantel treated sheep collected at different time intervals post treatment. Statistically significant differences (p < 0.0001) were observed in egg morphometry between the control and the treated groups in all the parameters studied. Eggs recovered from treated animals tend to be narrower and longer. Significant differences were found in the embryonation and hatching of eggs between 36 h post treatment (32, 5%) vs. approximately 85% in control, 12 h and 24 h post treatment. Our results confirm that closantel affects in vivo the normal development of the eggs. Sitio de la revista: https://www.sciencedirect.com/science/article/abs/pii/S0014489415300576?via%3Dihuben_US
dc.language.isoengen_US
dc.publisherEditorial Experimental Parasitologyen_US
dc.source160;
dc.subjectOvicidal activityen_US
dc.subjectFasciola hepaticaen_US
dc.subjectClosantelen_US
dc.subjectEgg hatch assayen_US
dc.titleIn vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.en_US
dc.typeArtículo Científicoen_US
umaza.description.filiationFil: Solana, María Victoria. Laboratorio de Biología Celular y Molecular, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.en_US
umaza.description.filiationFil: Mera y Sierra, Roberto. Centro de Investigación en Parasitología Regional (CIPAR), Universidad J.A. Maza, Guaymallén, Argentina.en_US
umaza.description.filiationFil: Scarcella, Silvana. Laboratorio de Biología Celular y Molecular, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.en_US
umaza.description.filiationFil: Neira, Gisela. Laboratorio de Biología Celular y Molecular, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.en_US
umaza.description.filiationFil: Solana, Hugo Daniel. Laboratorio de Biología Celular y Molecular, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.en_US
umaza.statusSNRDPublicadaen_US


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  • Ciencias Veterinarias [36]
    Artículos científicos publicados por equipos de investigación UMaza con resultados de proyectos realizados en las áreas disciplinares: ciencias veterinarias

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