Emerging insights into hypothalamic-pituitary- gonadal axis regulation and interaction with stress signalling.
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ARTÍCULO PUBLICADO EN REVISTA EXTERNA.Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex steroid secretion and function. In addition to guiding proper gonadal development and function, gonadal sex steroids also act in negative-and positive-feedback loops to regulate reproductive circuitry in the brain, including kisspeptin neurones, thereby modulating overall HPG axis status. Additional regulation is also provided by sex steroids made within the brain, including neuroprogestins. Furthermore, because reproduction and survival need to be coordinated and balanced, the HPG axis is able to modulate (and be modulated by) stress hormone signalling, including cortiscosterone, from the hypothalamic-pituitary- adrenal (HPA) axis. This review covers recent data related to the neural, hormonal and stress regulation of the HPG axis and emerging interactions between the HPG and HPA axes, focusing on actions at the level of the brain and pituitary. Sitio de la revista: https://pubmed.ncbi.nlm.nih.gov/29524268/Fil: Acevedo-Rodriguez, Alexandra. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.Fil: Kauffman, Alexander. Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.Fil: Cherrington, Brian. Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USAFil: Borges, Cibele. Department of Morphology, Institute of Biosciences, São Paulo State University (Unesp), Botucatu, BrazilFil: Roepke, Troy. Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USAFil: Laconi, Myriam. Laboratorio de Fisiopatología Ovárica, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET), Universidad Juan Agustín Maza, Mendoza, Argentina. Facultad de Ciencias Veterinarias y Ambientales, Universidad Juan Agustín Maza, Mendoza, Argentina. Facultad de Ciencias Médicas, Universidad de Mendoza, Mendoza, Argentina