Browsing by Author "Sanhuesa, María de los Ángeles"

Now showing items 1-2 of 2

    • Allopregnanolone alters follicular and luteal dynamics during the estrous cycle. 

      Asensio, Joana Antonela; Cáceres, Antonella Rosario Ramona; Pelegrina, Laura Tatiana; Sanhuesa, María de los Ángeles; Scotti, Leopoldina; Parborell, Fernanda; Laconi, Myriam Raquel (Comité editor Reproductive Biology and Endocrinology, 2018)
      Background: Allopregnanolone is a neurosteroid synthesized in the central nervous system independently of steroidogenic glands; it influences sexual behavior and anxiety. The aim of this work is to evaluate the indirect effect of a single pharmacological dose of allopregnanolone on important processes related to normal ovarian function, such as folliculogenesis, angiogenesis and luteolysis, and to study the corresponding changes in endocrine profile and enzymatic activity over 4 days of the rat estrous cycle. We test the hypothesis that allopregnanolone may trigger hypothalamus - hypophysis - ...

    • Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines 

      Pelegrina, Laura Tatiana; Sanhuesa, María de los Ángeles; Cáceres, Antonella Rosario Ramona; Cuello Carrión, Dario; Rodríguez, Cristina Elisa; Laconi, Myriam Raquel (Comité editorial Journal of Steroid Biochemistry and Molecular Biology, 2020-02)
      Ovarian carcinoma is one of the most common cause of death by gynecologic cancer. Several epidemiological and in vitro studies have shown controversial data about progesterone effects in ovarian cancer. Progesterone can be converted in its active metabolite, allopregnanolone, its effects in ovarian cancer are still unknown. Previously, we demonstrated that allopregnanolone modifies ovarian morphophysiology, being able to alter critical process of tumor development such as proliferation, apoptosis and angiogenesis. Taking into account these antecedents, we investigated the effect of progesterone ...