Browsing by Subject "5α-pregnanes"
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Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines (Comité editorial Journal of Steroid Biochemistry and Molecular Biology, 2020-02)ARTÍCULO PUBLICADO EN REVISTA EXTERNA. Ovarian carcinoma is one of the most common cause of death by gynecologic cancer. Several epidemiological and in vitro studies have shown controversial data about progesterone effects in ovarian cancer. Progesterone can be converted in its active metabolite, allopregnanolone, its effects in ovarian cancer are still unknown. Previously, we demonstrated that allopregnanolone modifies ovarian morphophysiology, being able to alter critical process of tumor development such as proliferation, apoptosis and angiogenesis. Taking into account these antecedents, ...